THERAPY DOSSIER · th-741e45d4aba8

Passage 3 rat tendon stem cells in chitosan/beta-glycerophosphate/collagen hydrogel (volume ratio 6:1:8; 2.0 wt% chitosan, 50 wt% beta-glycerophosphate, type I collagen 2 mg/ml)

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 28951538 ↗2017Mixed findings

Effect of Tendon Stem Cells in Chitosan/beta-Glycerophosphate/Collagen Hydrogel on Achilles Tendon Healing in a Rat Model.

RatOtherSprague-DawleyMalen = 114 rats in total; 96 used for the healing experiment, rand…Local implantation, injected around the injury site with a 1 ml syringe300 microlitres of hydrogel containing tendon stem cells; c…Immediately after creation of the defect, following closure of the skin incision

Model: Achilles tendon defect: the central one third of the left Achilles tendon (10 mm x 1 mm) was excised from the myotendinous junction to the calcaneus

Tendon stem cells combined with the chitosan/beta-glycerophosphate/collagen hydrogel significantly improved histology scores, increased collagen type I and scleraxis, reduced collagen type III and increased ultimate load and stiffness at 4 and 6 weeks versus control, hydrogel and cells alone. Tendo…

Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

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