Effect of curcumin on acute spinal cord injury in mice via inhibition of inflammation and TAK1 pathway.
MouseSpinal cord injuryContusionKM (Kunming)Femalen = 100 adult female mice randomised to 5 groups (control, mode…
Model: Acute traumatic spinal cord injury induced by the Allen weight-drop method
Curcumin concentration-dependently inhibited injury-induced TNF-alpha, IL-1beta, IL-6 and nitric oxide production, reduced phosphorylation of TAK1, MKK6 and p38 MAPK, down-regulated IkappaB and IKK, reduced GFAP expression at the medium and high doses, and significantly improved hindlimb functional…
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.