Effects of propranolol and clonidine on brain edema, blood-brain barrier permeability, and endothelial glycocalyx disruption after fluid percussion brain injury in the rat.
RatTBIFluid percussionSprague-DawleyMalen = 53 rats: propranolol n = 16, propranolol plus clonidine n =…InfusionEarly after trauma, continued for 24 hours
Model: Lateral fluid percussion traumatic brain injury
Brain water content did not differ between propranolol (80.8 plus or minus 0.3 per cent), propranolol plus clonidine (80.8 plus or minus 0.3 per cent) and vehicle (81.1 plus or minus 0.6 per cent). No effect was seen on blood-brain barrier permeability or motor scores. Unexpectedly, both treatments…
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