Protective effect of chlorogenic acid on the inflammatory damage of pancreas and lung in mice with l-arginine-induced pancreatitis.
MouseChemical/toxinC57BL/6MaleIntraperitoneal injection20 mg/kg or 40 mg/kg1 h before administration of l-arginine
Model: Acute pancreatitis and associated lung injury induced by two injections of l-arginine at 5 g/kg body weight
Chlorogenic acid at 40 mg/kg reduced the histological severity of pancreatitis and of pancreatitis-associated lung injury, lowered pancreatic enzyme activity, and reduced serum and pancreatic MIF levels in l-arginine-induced pancreatitis.
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