THERAPY DOSSIER · th-882f120edc97

Chlorogenic acid (CGA)

Nutraceutical · No mechanism record in ChEMBL for CHEMBL284616; pharmacology deliberately not asserted.

Evidence & regulatory context

Mechanism: No mechanism record in ChEMBL for CHEMBL284616; pharmacology deliberately not asserted.
Target: Not recorded
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: In trials, not approved
ChEMBL record: CHEMBL284616 ↗
ChEMBL max phase: 2 / 4 (development scale, not regulatory approval)
Synonyms: 5-CQA; trans-5-O-caffeoylquinic acid; Heriguard; NSC-70861
Note: Not recorded

Clinical trials 5

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02929901 ↗PHASE2/PHASE3completed

Coffee Constituents (Caffeine and Chlorogenic Acid) in NAFLD With Type 2 Diabetes

Type 2 Diabetes · Nonalcoholic Fatty Liver

Enrolment: 200 · Results not recorded

NCT02621060 ↗PHASE2completed

Chlorogenic Acid on Glycaemic Control, Insulin Secretion and Sensitivity in Impaired Glucose Tolerance

Impaired Glucose Tolerance

Enrolment: 30 · Results not recorded

NCT03444558 ↗NAcompleted

Natural Supplement Containing Chlorogenic Acid and Luteolin on Cardio-metabolic Risk in Metabolic Syndrome

Metabolic Syndrome

Enrolment: 100 · Results not recorded

NCT03019263 ↗NAcompleted

Berberine, Chlorogenic Acid and Tocotrienols for Menopause-associated Dyslipidaemia

Dyslipidemia

Enrolment: 63 · Results not recorded

NCT03520452 ↗NAcompleted

Effect of Chlorogenic Acids on the Human Vasculature

Endothelial Dysfunction

Enrolment: 22 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 28919396 ↗2017Reported benefit

Protective effect of chlorogenic acid on the inflammatory damage of pancreas and lung in mice with l-arginine-induced pancreatitis.

MouseChemical/toxinC57BL/6MaleIntraperitoneal injection20 mg/kg or 40 mg/kg1 h before administration of l-arginine

Model: Acute pancreatitis and associated lung injury induced by two injections of l-arginine at 5 g/kg body weight

Chlorogenic acid at 40 mg/kg reduced the histological severity of pancreatitis and of pancreatitis-associated lung injury, lowered pancreatic enzyme activity, and reduced serum and pancreatic MIF levels in l-arginine-induced pancreatitis.

Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.

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