Cytocompatible Anti-microbial Dressings of Syzygium cumini Cellulose Nanocrystals Decorated with Silver Nanoparticles Accelerate Acute and Diabetic Wound Healing.
MouseWoundSwiss albinon = Acute wound study: 9 groups of 6 mice; diabetic wound study…Topical, applied to the dorsal excision wound50 mg of ointment per wound per day; silver content approxi…Started after wounding and continued through the study period
Model: Full-thickness dorsal excision wound of 0.5 cm2 (8 mm diameter biopsy punch) in healthy mice and in streptozotocin-induced diabetic mice
Nanocomposite-treated acute and diabetic wounds closed faster, up to about 99% closure, with complete epithelialisation by day 8 in acute wounds and day 10 in diabetic wounds versus only partial re-epithelialisation in controls. Treatment reduced neutrophil influx, IL-6 and TNF-alpha and increased…
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