THERAPY DOSSIER · th-608d1faa6c98

Nanocomposite dressings of Syzygium cumini cellulose nanocrystals impregnated with silver nanoparticles (NC-1, NC-2, NC-3), applied as ointments and strips

Device

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Wound
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 28874762 ↗2017Reported benefit

Cytocompatible Anti-microbial Dressings of Syzygium cumini Cellulose Nanocrystals Decorated with Silver Nanoparticles Accelerate Acute and Diabetic Wound Healing.

MouseWoundSwiss albinon = Acute wound study: 9 groups of 6 mice; diabetic wound study…Topical, applied to the dorsal excision wound50 mg of ointment per wound per day; silver content approxi…Started after wounding and continued through the study period

Model: Full-thickness dorsal excision wound of 0.5 cm2 (8 mm diameter biopsy punch) in healthy mice and in streptozotocin-induced diabetic mice

Nanocomposite-treated acute and diabetic wounds closed faster, up to about 99% closure, with complete epithelialisation by day 8 in acute wounds and day 10 in diabetic wounds versus only partial re-epithelialisation in controls. Treatment reduced neutrophil influx, IL-6 and TNF-alpha and increased…

Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

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