RGMa inhibition with human monoclonal antibodies promotes regeneration, plasticity and repair, and attenuates neuropathic pain after spinal cord injury.
RatSpinal cord injuryCompressionWistarFemalen = 63 adult female Wistar rats in total: 40 for functional, BD…Intraspinal injection 1 mm rostral and 1 mm caudal to the lesion plus intravenous injection via internal jugular vein, later tail vein20 mg/kg intravenously per dose, plus two intraspinal injec…Immediately after injury
Model: Clip impact-compression spinal cord injury at T8, 20 g force for 1 minute with a modified aneurysm clip, following T9/10 laminectomy
AE12-1 improved BBB scores from 1 week post-injury and AE12-1Y from 6 weeks (12.6 versus 9.9 for PBS). Both antibodies improved ladderwalk success (68.4% and 64.2% versus 41% hIgG and 29% PBS) and CatWalk regularity index (89.3% and 88.3% versus 65.8% and 63.4%), increased perilesional neurons abou…
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