THERAPY DOSSIER · th-c10cc2968e90

Human anti-RGMa monoclonal antibodies AE12-1 and AE12-1Y

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 7

2 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT04295538 ↗Injury indicationPHASE2completed

Elezanumab in Acute Traumatic Cervical Spinal Cord Injury

Spinal Cord Injury

Enrolment: 60 · Results not recorded

NCT04278235 ↗Injury indicationEXPANDED_ACCESSno longer available

Expanded Access to Elezanumab

Acute Spinal Cord Injury

Enrolment not recorded · Results not recorded

NCT03737812 ↗PHASE2completed

Elezanumab Added to Standard of Care in Progressive Forms of Multiple Sclerosis

Multiple Sclerosis

Enrolment: 123 · Results not recorded

NCT03737851 ↗PHASE2completed

Elezanumab Added to Standard of Care in Relapsing Forms of Multiple Sclerosis

Multiple Sclerosis

Enrolment: 208 · Results not recorded

NCT04309474 ↗PHASE2completed

Elezanumab in Acute Ischemic Stroke

Acute Ischemic Stroke

Enrolment: 121 · Results not recorded

NCT02601885 ↗PHASE1completed

Escalating Multiple Dose Study of ABT-555 in Relapsing Forms of Multiple Sclerosis

Multiple Sclerosis

Enrolment: 20 · Results not recorded

NCT02606630 ↗PHASE1terminated

[C-11]-PBR28 PET Study of ABT-555 on CNS Inflammation in Relapsing MS

Multiple Sclerosis

Enrolment: 4 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 28874746 ↗2017Reported benefit

RGMa inhibition with human monoclonal antibodies promotes regeneration, plasticity and repair, and attenuates neuropathic pain after spinal cord injury.

RatSpinal cord injuryCompressionWistarFemalen = 63 adult female Wistar rats in total: 40 for functional, BD…Intraspinal injection 1 mm rostral and 1 mm caudal to the lesion plus intravenous injection via internal jugular vein, later tail vein20 mg/kg intravenously per dose, plus two intraspinal injec…Immediately after injury

Model: Clip impact-compression spinal cord injury at T8, 20 g force for 1 minute with a modified aneurysm clip, following T9/10 laminectomy

AE12-1 improved BBB scores from 1 week post-injury and AE12-1Y from 6 weeks (12.6 versus 9.9 for PBS). Both antibodies improved ladderwalk success (68.4% and 64.2% versus 41% hIgG and 29% PBS) and CatWalk regularity index (89.3% and 88.3% versus 65.8% and 63.4%), increased perilesional neurons abou…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.

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