Quercetin attenuates the ischemia reperfusion induced COX-2 and MPO expression in the small intestine mucosa.
RatIschaemia-reperfusionIntestinal / mesentericCharles River Wistar, specific pathogen-freeMalen = 45 ratsIntraperitoneal30 min before onset of ischaemia
Model: Superior mesenteric artery occlusion for 1 h followed by reperfusion for 1, 4 or 24 h
Quercetin significantly reduced the mucosal injury index at 4 h of reperfusion together with lower COX-2 expression in villous epithelium, and lowered myeloperoxidase-positive cell numbers in the lamina propria in both acute and late phases, with a significant reduction at 24 h.
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