Emodin alleviates severe acute pancreatitis-associated acute lung injury by decreasing pre-B-cell colony-enhancing factor expression and promoting polymorphonuclear neutrophil apoptosis.
RatChemical/toxinSprague-DawleyMalen = 30 rats in total, 6 per group across five groupsIntraperitoneal10 mg/kg body weight in vivo; 30 micrograms/ml in vitro3 h after induction of severe acute pancreatitis
Model: Severe acute pancreatitis with associated acute lung injury induced by retrograde injection of 5 per cent sodium taurocholate at 1 ml/kg into the biliary-pancreatic duct under chloral hydrate anaesthesia
Emodin, like FK866 and dexamethasone, significantly downregulated pre-B-cell colony-enhancing factor in peripheral blood neutrophils, reduced serum amylase activity and lung and pancreas wet to dry weight ratios, alleviated lung and pancreatic histological injury and promoted neutrophil apoptosis t…
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