Hyperbaric Oxygen Therapy After Acute Thoracic Spinal Cord Injury: Improvement of Locomotor Recovery in Rats.
RatSpinal cord injuryContusionWistarFemalen = 72 female Wistar rats; 35 mild and 35 moderate injuries; 5…Hyperbaric chamber2.5 atm for 1 hour per session30 minutes or 12 hours after injury
Model: Thoracic laminectomy followed by MASCIS weight-drop impactor from 12.5 mm (mild) or 25 mm (moderate) height
All animals receiving hyperbaric therapy showed significant improvement in motor function and histology compared with controls, with earlier motor recovery and smaller histological injury when therapy was started sooner and given for 7 days.
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