Hsp90 regulation affects the treatment of glucocorticoid for pancreatitis-induced lung injury.
MouseOtherBALB/c and C57BL/6Male0.4 mg/kg and 4 mg/kg
Model: Acute pancreatitis with secondary acute lung injury
C57BL/6 mice showed lower mortality, less lung water and lower IL-1beta than BALB/c mice and responded better to 0.4 mg/kg dexamethasone with greater glucocorticoid receptor binding to the glucocorticoid responsive element; a higher dose of 4 mg/kg reduced mortality in both strains, and the protect…
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