Osthole promotes endogenous neural stem cell proliferation and improved neurological function through Notch signaling pathway in mice acute mechanical brain injury.

Osthole promotes endogenous neural stem cell proliferation and improved neurological function through Notch signaling pathway in mice acute mechanical brain injury.

Model: Cortical stab wound mechanical brain injury

Osthole promoted endogenous neural stem cell proliferation, increased neuron numbers in the injured cortex and hippocampal DG and CA3 and improved learning and memory in the Morris water maze; these effects were abolished by the Notch inhibitor DAPT, indicating Notch pathway involvement.

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