The effect of molecular weight and concentration of hyaluronan on the recovery of the rat sciatic nerve sustaining acute traumatic injury.
RatCrushPeripheral-nerve crushSprague-DawleyMaleLocal application to the injured nerveAt the time of crush injury
Model: Sciatic nerve crush injury
High molecular weight (3000 kDa) hyaluronan gave better overall recovery than lower molecular weight preparations, with the anti-inflammatory effect proposed as the mechanism. The authors conclude hyaluronan properties must be optimised for use in acute traumatic peripheral nerve injury.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.