0.8% Hyaluronic Acid Gel in Treatment of Moderate to Severe Chronic Periodontitis
Periodontitis
Enrolment: 24 · Results not recorded
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Device · No mechanism record retrieved; ChEMBL molecule_type Unknown. ATC M09AX01, S01KA01, D03AX05, R01AX09.
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Periodontitis
Enrolment: 24 · Results not recorded
Cataract · Floppy Iris Syndrome
Enrolment: 28 · Results not recorded
Presbyopia
Enrolment: 11 · Results not recorded
Adhesion · Thyroid Diseases
Enrolment: 100 · Results not recorded
Dry Eye
Enrolment: 219 · Results not recorded
Periodontitis · Gingival Recession
Enrolment: 70 · Results not recorded
Alveolar Osteitis
Enrolment: 60 · Results not recorded
Midface Volume Deficit
Enrolment: 111 · Results not recorded
Knee Osteoarthritis
Enrolment: 102 · Results not recorded
Osteo Arthritis Knee
Enrolment: 40 · Results not recorded
Sodium Hyaluronate
Enrolment: 40 · Results not recorded
Osteoarthritis of the Shoulder
Enrolment: 300 · Results not recorded
Acne Scars
Enrolment: 30 · Results not recorded
Temporomandibular Joint Osteoarthritis
Enrolment: 28 · Results not recorded
Osteoarthritis Knee · Degeneration; Articular Cartilage, Knee
Enrolment: 21 · Results not recorded
Aging Problems
Enrolment: 74 · Results not recorded
Peri-implant Mucositis · Mucositis Oral
Enrolment: 92 · Results not recorded
3 studies reported at therapy level; 3 evidence entries itemised.
Model: Sciatic nerve crush injury
High molecular weight (3000 kDa) hyaluronan gave better overall recovery than lower molecular weight preparations, with the anti-inflammatory effect proposed as the mechanism. The authors conclude hyaluronan properties must be optimised for use in acute traumatic peripheral nerve injury.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.
Model: Ultrasound-guided intratendinous injection into healthy Achilles tendon, with needle puncture only as control
Both hyaluronate and phosphate buffered saline injections produced acute tendon injury and inflammation persisting to day 42. Hyaluronate caused significantly worse histopathological scores, higher ED1-positive and ED2-positive macrophage densities (peak values 7112 plus or minus 1540 per mm3 and 2…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
Model: Traumatic urethral injury and inflammation created by introducing a tiny hook and drawing it at the 12 o'clock position within the urethra
No group showed inflammation at the end of the study. Calcification, haemorrhage and stenosis occurred in all trauma groups. Tissue thickness increased significantly in the saline-treated group (p=0.004), but neither hyaluronic acid 1.8% nor 3% differed significantly from saline, indicating no bene…
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.