Acute ethanol administration results in a protective cytokine and neuroinflammatory profile in traumatic brain injury.
MouseTBIWeight-drop / impact-accelerationC57BL/6MaleOral administrationPretreatment before injury
Model: Closed blunt weight-drop traumatic brain injury, with and without traumatic intracerebral haemorrhage
Ethanol pretreatment produced faster and more complete neurological recovery after weight-drop TBI, with reduced leukocyte infiltration and microglial activation. Parenchymal GM-CSF, IL-6 and IL-3 fell and IL-13 and VEGF were transiently raised, with a delayed IL-6 peak and suppressed GM-CSF, IFN-g…
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