Effects of Berberine on Acute Necrotizing Pancreatitis and Associated Lung Injury.
MouseChemical/toxinC57BL/6FemaleIntraperitonealAdministered during the CDE diet, that is concurrent with injury induction
Model: Severe acute necrotising pancreatitis induced by a choline-deficient ethionine-supplemented (CDE) diet fed for 3 days, with associated lung injury
Berberine significantly reduced histological damage to pancreas and lung, lowered serum amylase and lipase, myeloperoxidase activity, cytokine production and mortality, and inhibited activation of NF-kappa B, JNK and p38 in the pancreas.
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