Effects of photobiomodulation therapy and topical non-steroidal anti-inflammatory drug on skeletal muscle injury induced by contusion in rats-part 2: biochemical aspects.
RatCrushLimb / muscle crushWistarMaleTranscutaneous laser irradiation; topical gel for diclofenacPhotobiomodulation 830 nm, continuous mode, 100 mW power, 3…1 h after injury
Model: Controlled contusion (trauma) of the anterior tibial muscle
Photobiomodulation at 1, 3 and 9 J reduced TNF-alpha and COX-2 gene expression at all assessed times compared with the injury and diclofenac groups (p < 0.05), while diclofenac reduced COX-2 only relative to injury. COX-2 protein expression was unchanged except with the 3 J dose at 12 h. Photobiomo…
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