THERAPY DOSSIER · th-f7e4568f6e85

Photobiomodulation therapy (830 nm laser) compared with topical diclofenac sodium

Device

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Crush
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 2

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT07699679 ↗Injury indicationNAnot yet recruiting

Impact of Photobiomodulation in Coronary Artery Bypass Surgery (Saphenous Vein Wound Healing)

Surgical Wound Healing

Enrolment: 292 · Results not recorded

NCT06703762 ↗NAnot yet recruiting

Efficacy of Photobiomodulation on Wound Healing and IL-6 in Neuropathic Foot Ulcer

Neuropathic Foot Ulcer

Enrolment: 68 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 28795275 ↗2017Reported benefit

Effects of photobiomodulation therapy and topical non-steroidal anti-inflammatory drug on skeletal muscle injury induced by contusion in rats-part 2: biochemical aspects.

RatCrushLimb / muscle crushWistarMaleTranscutaneous laser irradiation; topical gel for diclofenacPhotobiomodulation 830 nm, continuous mode, 100 mW power, 3…1 h after injury

Model: Controlled contusion (trauma) of the anterior tibial muscle

Photobiomodulation at 1, 3 and 9 J reduced TNF-alpha and COX-2 gene expression at all assessed times compared with the injury and diclofenac groups (p < 0.05), while diclofenac reduced COX-2 only relative to injury. COX-2 protein expression was unchanged except with the 3 J dose at 12 h. Photobiomo…

Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.72. Machine-extracted fields require source verification.

Loading the evidence…