Bone marrow mesenchymal stem cells ameliorate lung injury through anti-inflammatory and antibacterial effect in COPD mice.
MouseOtherC57BL/6MaleTransplantation (route not stated in abstract)
Model: Chronic obstructive pulmonary disease lung injury induced by cigarette smoke, with acute exacerbation induced by Haemophilus parainfluenzae infection
Compared with the COPD plus Haemophilus parainfluenzae group, mesenchymal stem cell treatment increased TSG-6, suppressed NF-kappa B signalling, reduced proinflammatory cytokines, increased IL-10 and significantly reduced lung injury score, while enhancing alveolar macrophage phagocytic activity an…
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