The Efficacy of Mesenchymal Stem Cells for Stimulate the Union in Treatment of Non-united Tibial and Femoral Fractures in Shahid Kamyab Hospital
Nonunion Fracture
Enrolment: 19 · Results not recorded
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Biologic
2 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Nonunion Fracture
Enrolment: 19 · Results not recorded
Defect of Articular Cartilage · Cartilage Injury · Osteoarthritis, Knee
Enrolment: 4 · Results not recorded
Evidence of Liver Transplantation
Enrolment: 80 · Results not recorded
Autoimmune Pulmonary Alveolar Proteinosis
Enrolment: 10 · Results not recorded
Multiple Sclerosis
Enrolment: 2 · Results not recorded
Myocardial Infarction
Enrolment: 20 · Results not recorded
Type 2 Diabetes Mellitus
Enrolment: 60 · Results not recorded
Leg Length Inequality
Enrolment: 6 · Results not recorded
Ulcerative Colitis · Inflammatory Bowel Diseases
Enrolment: 4 · Results not recorded
Knee Osteoarthritis
Enrolment: 35 · Results not recorded
6 studies reported at therapy level; 6 evidence entries itemised.
Model: Chronic obstructive pulmonary disease lung injury induced by cigarette smoke, with acute exacerbation induced by Haemophilus parainfluenzae infection
Compared with the COPD plus Haemophilus parainfluenzae group, mesenchymal stem cell treatment increased TSG-6, suppressed NF-kappa B signalling, reduced proinflammatory cytokines, increased IL-10 and significantly reduced lung injury score, while enhancing alveolar macrophage phagocytic activity an…
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Model: Multiple trauma followed by lipopolysaccharide administration to induce acute lung injury
Bone marrow mesenchymal stem cells reduced lung inflammatory injury, suppressed TLR2 and TLR4 expression and p65 phosphorylation, lowered pro-inflammatory cytokines and raised IL-10.
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Model: Radiation-induced acute skin damage produced by irradiating the hind legs with a linear accelerator at 45 Gy
Skin damage was milder and healing faster in the BMSC group than in controls, with a significantly lower wound score (P<0.05). PGE2 and TGF-beta1 expression were significantly lower and SDF-1 expression significantly higher in the BMSC group (P<0.05), consistent with reduced inflammation and fibros…
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Model: Incomplete spinal cord injury in adult mice
Intramuscular injection of bone marrow mesenchymal stem cells into both hindlimbs improved motor skills by 5 months and was associated with spinal cord repair on MRI and immunohistochemistry.
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Model: Weight-drop traumatic brain injury
Single and combined transplantation significantly improved neurological severity scores. Grafted animals had more neurons and regenerated axons and fewer astrocytes at 14 days (P<0.05). Ciliary neurotrophic factor expression fell significantly in the co-transplantation group and the JAK/STAT pathwa…
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Model: 70% hepatic ischemia-reperfusion injury
Systemic MSC infusion significantly reduced liver enzyme release and improved histology of the acutely injured liver. MSC conditioned medium promoted hepatocyte proliferation and directly inhibited hydrogen peroxide induced apoptosis, with prevention of MEK/ERK pathway activation identified as pivo…
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