Antiseptic toxicity in wounds healing by secondary intention.
RatWoundSprague-DawleyfemaleTopical application to the wound
Model: 10 mm skin defects healing by secondary intention
Chloramine T significantly delayed collagen production and prolonged the acute inflammatory response compared with saline, whereas chlorhexidine did not differ from saline. The authors conclude that hypochlorite antiseptics may adversely affect healing by secondary intention.
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