Evidence & regulatory context
- Mechanism
- Cell membrane inhibitor (INHIBITOR); disrupts the bacterial cell membrane
- Target
- CHEMBL2364031
- Injury models
- Wound
- Reported indication
- Chlorhexidine - topical antiseptic/disinfectant (skin preparation, surgical scrub) and oral rinse for gingivitis; long-standing approval
- First approval
- 1976
- Development stage
- Approved antiseptic/oral-care agent; not approved for an acute injury indication
- ChEMBL max phase
- 4 / 4 (development scale, not regulatory approval)
- Synonyms
- Chlorhexidine; Chlorhexidine gluconate; Hibiclens; Hibiscrub; Corsodyl; Peridex; Avagard
- Note
- Not recorded
Clinical trials 1
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Clinical and Laboratorial Evaluation of the Effect of Sodium Hypochlorite, Chloramine T and Ricinus Communis Solutions in Candida Species Identified in the Biofilm of Total Prostheses and Palate of Total Edentulous Individuals.
Candidiasis · Biofilms · Candida Infection
Enrolment: 108 · Results not recorded
Preclinical evidence 1
1 studies reported at therapy level; 1 evidence entries itemised.
RatWoundSprague-DawleyfemaleTopical application to the wound
Model: 10 mm skin defects healing by secondary intention
Chloramine T significantly delayed collagen production and prolonged the acute inflammatory response compared with saline, whereas chlorhexidine did not differ from saline. The authors conclude that hypochlorite antiseptics may adversely affect healing by secondary intention.
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.