Ghrelin Therapy Decreases Incidents of Intracranial Hemorrhage in Mice after Whole-Body Ionizing Irradiation Combined with Burn Trauma.
MouseRadiationB6D2F1/JFemalen = 20 to 22 mice per group for survival experiments, 10 mice p…Intravenous, lateral tail vein113 µg/kg per dose in 0.2 mL24, 48 and 72 hours after the combined injury
Model: Whole-body bilateral Cobalt-60 gamma irradiation at 9.5 Gy (0.4 Gy per minute) followed within 1 hour by a 15% total body surface area dorsal skin burn produced by igniting 0.25 mL of 95% ethanol for 12 seconds
Radiation combined with burn trauma produced cerebro-vascular impairment, intracranial haemorrhage and platelet depletion. Ghrelin given after the combined injury significantly reduced the intracranial haemorrhage score ratio and platelet depletion compared with vehicle.
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