Therapeutic Effects of 6-Gingerol, 8-Gingerol, and 10-Gingerol on Dextran Sulfate Sodium-Induced Acute Ulcerative Colitis in Rats.
RatChemical/toxinSprague-DawleyMaleIntraperitoneal30 mg/kg per day for each gingerolStarted after the 7-day dextran sulfate sodium induction period
Model: Acute ulcerative colitis induced by 5% (w/v) dextran sulfate sodium in drinking water for 7 consecutive days
All three gingerols attenuated colitic symptoms, raised superoxide dismutase activity, lowered malondialdehyde and myeloperoxidase in colon tissue, reduced serum tumour necrosis factor alpha and interleukin 1 beta, and accelerated mucosal healing, with broadly equal efficacy between the three analo…
Extraction: extract · Supplied extraction confidence: 0.72. Machine-extracted fields require source verification.