THERAPY DOSSIER · th-62b3a6d32f41

6-Gingerol, 8-gingerol and 10-gingerol

Nutraceutical

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: In trials, not approved
ChEMBL record: CHEMBL402978 ↗
ChEMBL max phase: -1 / 4 (development scale, not regulatory approval)
Synonyms: 6-gingerol; [6]-gingerol; Gingerol
Note: Not recorded

Clinical trials 2

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT05882864 ↗PHASE4unknown

Efficacy of Ginger Muco-bioadhesive Gel (6-Gingerol) in Management of Oral Lichen Planus

Oral Lichen Planus

Enrolment: 28 · Results not recorded

NCT07488416 ↗NArecruiting

Lesion Sterilization and Tissue Repair Using Zinc Oxide/6-gingerol Mix vs Triple Antibiotic Paste in Primary Molars

Lesion Sterilization · Tissue Repair

Enrolment: 60 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 28762585 ↗2017Reported benefit

Therapeutic Effects of 6-Gingerol, 8-Gingerol, and 10-Gingerol on Dextran Sulfate Sodium-Induced Acute Ulcerative Colitis in Rats.

RatChemical/toxinSprague-DawleyMaleIntraperitoneal30 mg/kg per day for each gingerolStarted after the 7-day dextran sulfate sodium induction period

Model: Acute ulcerative colitis induced by 5% (w/v) dextran sulfate sodium in drinking water for 7 consecutive days

All three gingerols attenuated colitic symptoms, raised superoxide dismutase activity, lowered malondialdehyde and myeloperoxidase in colon tissue, reduced serum tumour necrosis factor alpha and interleukin 1 beta, and accelerated mucosal healing, with broadly equal efficacy between the three analo…

Extraction: extract · Supplied extraction confidence: 0.72. Machine-extracted fields require source verification.

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