Radiation protection and mitigation potential of phenylbutyrate: delivered via oral administration.
MouseRadiationDBAMaleOral10 mg/kg in vivo; 50 µM in vitroPre-radiation for the radioprotection arm and post-radiation for the mitigation…
Model: Acute whole-body gamma irradiation at 7 to 11.5 Gy, with a 30-day lethality endpoint; parallel in vitro work in human osteoblast (HOS) cells
Oral phenylbutyrate before irradiation gave a dose reduction factor of 1.25 (p = 0.001) and after irradiation a dose reduction factor of 1.18 (p = 0.05). Treatment was associated with significant elevations in neutrophils and platelets, attenuated DNA damage, and restored radiation-reduced acetylat…
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