Protective effects of tannic acid on acute doxorubicin-induced cardiotoxicity: Involvement of suppression in oxidative stress, inflammation, and apoptosis.
RatChemical/toxinSprague-DawleyMale20 and 40 mg/kgStarted 3 days before doxorubicin and continued after it, with doxorubicin inje…
Model: Acute cardiotoxicity induced by a single intraperitoneal injection of doxorubicin 10 mg/kg
Tannic acid pretreatment normalised serum lactate dehydrogenase, creatine kinase and creatine kinase-MB, raised antioxidant enzyme activity and lowered malondialdehyde, suppressed tumour necrosis factor alpha, interleukin 1 beta, endothelin 1 and NF-kappaB, and reduced apoptotic signalling.
Extraction: extract · Supplied extraction confidence: 0.72. Machine-extracted fields require source verification.