Effects of exogenous thymosin beta4 on carbon tetrachloride-induced liver injury and fibrosis.
MixedChemical/toxinBalb/c mice; Sprague-Dawley ratsMale Balb/c mice; sex of Sprague-Dawley rats not separately statedn = Mice n = 10 per group across four groups (40 total); rats c…IntraperitonealMice 100 micrograms per mouse per dose; rats 1 mg/kg body w…Mice: first dose at 0 hours, concurrent with carbon tetrachloride injection. Ra…
Model: Acute injury in mice: single intraperitoneal injection of carbon tetrachloride 0.5 mL/kg body weight in olive oil, sacrifice at 24 hours. Fibrosis in rats: carbon tetrachloride 0.5 mL/kg body weight in olive oil intraperitoneally twice weekly for 8 weeks
Exogenous thymosin beta-4 significantly lowered serum ALT and AST, reduced necrosis, MDA, nitro-tyrosine, TNF-alpha, IL-1beta and NF-kappaB p65, and restored SOD activity and glutathione in carbon tetrachloride-treated mice. In rats it reduced hepatic hydroxyproline, collagen deposition, pseudo-lob…
Extraction: extract · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.