RGN-259 Ophthalmic Solution for Neurotrophic Keratopathy (SEER-1)
Neurotrophic Keratopathy
Enrolment: 18 · Results not recorded
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Biologic
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Neurotrophic Keratopathy
Enrolment: 18 · Results not recorded
Neurotrophic Keratopathy
Enrolment: 70 · Results not recorded
Venous Stasis Ulcers
Enrolment: 72 · Results not recorded
Pressure Ulcers
Enrolment: 72 · Results not recorded
Epidermolysis Bullosa
Enrolment: 30 · Results not recorded
Diabetes
Enrolment: 12 · Results not recorded
Dry Eye Syndrome
Enrolment: 72 · Results not recorded
Acute Myocardial Infarction
Enrolment: 90 · Results not recorded
Acute Myocardial Infarction · STEMI
Enrolment: 0 · Results not recorded
Atherosclerotic Cardiovascular Disease · Endothelial Dysfunction
Enrolment: 80 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Acute injury in mice: single intraperitoneal injection of carbon tetrachloride 0.5 mL/kg body weight in olive oil, sacrifice at 24 hours. Fibrosis in rats: carbon tetrachloride 0.5 mL/kg body weight in olive oil intraperitoneally twice weekly for 8 weeks
Exogenous thymosin beta-4 significantly lowered serum ALT and AST, reduced necrosis, MDA, nitro-tyrosine, TNF-alpha, IL-1beta and NF-kappaB p65, and restored SOD activity and glutathione in carbon tetrachloride-treated mice. In rats it reduced hepatic hydroxyproline, collagen deposition, pseudo-lob…
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