Interleukin-1 Receptor in Seizure Susceptibility after Traumatic Injury to the Pediatric Brain.
MouseTBIControlled cortical impactC57BL/6 (per MeSH indexing)MaleSubcutaneous100 mg/kgTreated acutely after injury; exact hours not stated
Model: Controlled cortical impact or sham surgery at postnatal day 21, approximating a toddler-aged child; impact device, velocity, depth and dwell time not available
IL-1Ra reduced seizure susceptibility at 2 weeks post-injury versus vehicle and lowered hippocampal astrogliosis. In the chronic arm, IL-1Ra-treated injured mice showed improved spatial memory at 4 months, fewer evoked seizures at 6 months and greater preservation of cortical tissue.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.