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PRECLINICAL PUBLICATION · 2017

Exogenous Acrolein intensifies sensory hypersensitivity after spinal cord injury in rat.

Rat / Spinal cord injury

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 28716263 ↗2017Mixed findings

Exogenous Acrolein intensifies sensory hypersensitivity after spinal cord injury in rat.

RatSpinal cord injuryContusionSprague-DawleyMale

Model: Contusion spinal cord injury, with subsequent acute or delayed nasal exposure to acrolein at concentrations similar to those in cigarette smoke, or to actual cigarette smoke

Nasal acrolein exposure and cigarette smoke both intensified neuropathic pain behaviours after contusion spinal cord injury, with smoke effects persisting at least one week after cessation, and this coincided with raised urinary acrolein-glutathione metabolite. The acrolein scavenger phenelzine red…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.