Neonatal Injury Results in Sex-Dependent Nociceptive Hypersensitivity and Social Behavioral Deficits During Adolescence, Without Altering Morphine Response.
RatWoundSprague-DawleyMale and femaleAdministered during adolescence, postnatal day 28 to 40, well after the neonata…
Model: Hindpaw plantar incision (surgical) injury at postnatal day 3
Neonatal plantar incision produced mechanical hypersensitivity resolving within 24 hours, but in adolescence male rats showed ipsilaterally restricted mechanical, heat and cold hypersensitivity and social behavioural deficits, whereas females did not. Neonatal injury did not alter acute morphine an…
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