Effects of the essential oil of Alpinia zerumbet (Pers.) B.L. Burtt & R.M. Sm. on healing and tissue repair after partial Achilles tenotomy in rats.
RatOtherWistarMalen = 30 Wistar rats divided into two groups, with each animal se…Topical application to the operated hind pawDiluted to 33 per cent, 0.3 mL/kgFollowing partial Achilles tenotomy
Model: Partial Achilles tenotomy, right hind paw treated and left hind paw used as internal control
Alpinia zerumbet essential oil reduced hyperaemia and inflammatory cell number in the acute phase (p less than 0.001) and, in the sub-acute phase, macrophage counts correlated with fibroblasts (r = 0.17, p = 0.03). At the chronic phase, treated tendons had more fibroblasts and a higher proportion o…
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