Dexmedetomidine protects against renal ischemia and reperfusion injury by inhibiting the P38-MAPK/TXNIP signaling activation in streptozotocin induced diabetic rats.
RatIschaemia-reperfusionRenalSprague-DawleyMalen = Four groups of six rats each, 24 in totalIntraperitoneal50 micrograms/kgAdministered 30 minutes before ischaemia
Model: Streptozotocin-induced diabetes (single 65 mg/kg intraperitoneal dose) followed by renal ischaemia-reperfusion produced by 25 minutes of bilateral renal pedicle clamping and 48 hours of reperfusion
Renal ischaemia-reperfusion in diabetic rats significantly increased injury, TNF-alpha, IL-1beta, oxidative stress and apoptosis, alongside raised phosphorylated p38-MAPK and TXNIP. Dexmedetomidine pre-treatment reversed all of these changes, which the authors attributed partly to inhibition of p38…
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