eIF2alpha signaling regulates ischemic osteonecrosis through endoplasmic reticulum stress.
RatIschaemia-reperfusionOther / unspecifiedSprague-DawleyMalen = 60 rats in total: sham n = 18, osteonecrosis n = 18, osteon…Subcutaneous0.05 mg/kg in vivo, dissolved in propylene glycol; in vitro…Commenced after surgery
Model: Surgically induced ischaemic osteonecrosis of the bilateral femoral heads: femoral head dislocated, ligamentum teres transected and a 3-0 Vicryl ligature tightly placed around the femoral neck; sham animals underwent the same procedure without ligation or capsular transection
Salubrinal significantly increased BV/TV, Tb.N, Tb.Th, bone mineral density and content, bone area fraction, osteoblast and CFU-F numbers and vessel number and area, while reducing Tb.Sp, empty lacunae, osteoclast surface and osteoclast formation, migration, adhesion and pit formation in the osteon…
Extraction: extract · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.