3 studies reported at therapy level; 3 evidence entries itemised.
RatIschaemia-reperfusionOther / unspecifiedSprague-DawleyMalen = 60 rats in total: sham n = 18, osteonecrosis n = 18, osteon…Subcutaneous0.05 mg/kg in vivo, dissolved in propylene glycol; in vitro…Commenced after surgery
Model: Surgically induced ischaemic osteonecrosis of the bilateral femoral heads: femoral head dislocated, ligamentum teres transected and a 3-0 Vicryl ligature tightly placed around the femoral neck; sham animals underwent the same procedure without ligation or capsular transection
Salubrinal significantly increased BV/TV, Tb.N, Tb.Th, bone mineral density and content, bone area fraction, osteoblast and CFU-F numbers and vessel number and area, while reducing Tb.Sp, empty lacunae, osteoclast surface and osteoclast formation, migration, adhesion and pit formation in the osteon…
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RatTBIBlast / overpressureSprague-Dawley1 mg/kgPost-blast
Model: Blast traumatic brain injury at 50 psi
Blast injury increased p-PERK and p-eIF2alpha at 30 min, p-T205 tau at 6 h and iron at 24 h in the left cortex, with behavioural changes on the Forced Swim Test at 72 h, Elevated Plus Maze at 7 days and learning disruption on the Morris Water Maze at 21 days. Salubrinal reduced ER stress markers in…
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RatTBIBlast / overpressureSprague-DawleyMalen = 51 male rats in total: 24 single-blast rats (n=4 per treatm…Intraperitoneal injection, dissolved in 0.5% DMSO1 mg/kg5 min after each blast exposure
Model: Blast overpressure exposure, single blast TBI and repetitive blast TBI paradigm
Salubrinal given acutely after blast reduced endoplasmic reticulum stress, oxidative stress and neuroinflammatory markers at 24 h after single injury, attenuated iNOS activity at 72 h after repetitive injury, and prevented impulsive-like behaviour on the elevated plus maze.
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