Epigallocatechin Gallate Attenuates Hip Fracture-Induced Acute Lung Injury by Limiting Mitochondrial DNA (mtDNA) Release.
RatFractureFemurSprague-DawleyMalen = 30 rats: control n = 10, hip fracture n = 10, hip fracture…Intraperitoneal10 mg/kg10 minutes before the fracture was induced
Model: Closed unilateral hip fracture by blunt guillotine impact: anaesthetised rats placed prone on a blunt guillotine ramming apparatus aimed at the proximal femur, with the guillotine lifted to 15 cm and released in free fall
EGCG pre-treatment significantly reduced the fracture-induced rise in serum mitochondrial DNA, lung injury score, lung wet to dry ratio, bronchoalveolar lavage total cell, monocyte/macrophage and neutrophil counts, and bronchoalveolar lavage TNF-alpha and IL-6 (all p less than 0.05).
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