Ascorbate lacks significant influence in rats with bile duct ligation-induced liver injury.
RatOtherSprague-DawleyMaleOral gavage250 mg/kg/dayStarted on the first day after bile duct ligation
Model: Common bile duct ligation-induced chronic liver injury (hepatitis at day 8, cirrhosis at day 29)
Ascorbate did not influence hepatitis, oxidative stress, fibrosis or haemodynamic parameters in bile duct ligated rats, and intrahepatic and collateral vasoresponsiveness, mesenteric angiogenesis and shunting severity were also unaffected.
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