Fentanyl Ameliorates Severe Acute Pancreatitis-Induced Myocardial Injury in Rats by Regulating NF-κB Signaling Pathway.
RatChemical/toxinSprague-DawleyMalen = 30 rats in total, 10 per group (sham, SAP, fentanyl+SAP)Intravenous30 ug/kg in 0.5 ml saline23-23.5 h after induction of severe acute pancreatitis, infused over 30-60 min
Model: Severe acute pancreatitis induced by retrograde pancreatic duct injection of 5% sodium taurocholate (1 ml/kg at 0.1 ml/min), with secondary myocardial injury
Fentanyl reduced serum CK-MB (1806 to 1020 u/ml) and LDH (1516 to 993 u/l), lowered myocardial apoptotic index, improved pancreatic (10.3 to 5.7) and cardiac (2.9 to 1.8) histopathological scores, suppressed IL-1beta and IL-6 and restored IkappaB.
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