Intranasal Fentanyl Versus Intravenous Morphine in the Emergency Department Treatment of Severe Painful Sickle Cell Crises in Children
Pain · Sickle Cell Disease
Enrolment: 31 · Results not recorded
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Drug · Mu opioid receptor agonist (AGONIST; direct interaction, disease efficacy)
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Pain · Sickle Cell Disease
Enrolment: 31 · Results not recorded
Pain, Postoperative · Otitis Media
Enrolment: 150 · Results not recorded
Chronic Pain
Enrolment: 0 · Results not recorded
Analgesic · Sedative · Mechanical Ventilation · Children
Enrolment: 54 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Severe acute pancreatitis induced by retrograde pancreatic duct injection of 5% sodium taurocholate (1 ml/kg at 0.1 ml/min), with secondary myocardial injury
Fentanyl reduced serum CK-MB (1806 to 1020 u/ml) and LDH (1516 to 993 u/l), lowered myocardial apoptotic index, improved pancreatic (10.3 to 5.7) and cardiac (2.9 to 1.8) histopathological scores, suppressed IL-1beta and IL-6 and restored IkappaB.
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.