Pre-treatment with spermine for acute cerebral ischemia/reperfusion injuries.
RatIschaemia-reperfusionCerebral (MCAO/stroke)Sprague-DawleyMalen = 60 rats: sham n=12, model n=12, spermine 10 mg/kg n=12, 25…10, 25 or 50 mg/kgOne week before establishment of the ischaemia/reperfusion model (pre-treatment)
Model: Acute cerebral ischaemia/reperfusion by intraluminal suture occlusion for 2 h followed by suture removal
Spermine pre-treatment produced dose-dependent reductions in neurological deficit scores and MDA, increased SOD activity, and shifted the Bax/Bcl-2 balance towards survival compared with untreated model rats.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.