Lysophosphatidic Acid Protects Against Endotoxin-Induced Acute Kidney Injury.
MouseEndotoxin/LPSC57BL/6Intraperitoneal5 mg/kg1 h before lipopolysaccharide injection (pre-treatment)
Model: Lipopolysaccharide (endotoxin)-induced acute kidney injury, assessed 24 h after LPS
LPA 18:1 pre-treatment reduced LPS-induced elevation of plasma urea and creatinine, attenuated renal inflammatory cytokine upregulation, preserved PGC-1alpha and haem oxygenase-1 expression and mitochondrial ultrastructure, and reduced cytokine induction in macrophages in vitro.
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