Effects of prostaglandin lipid mediators on agonist-induced lung endothelial permeability and inflammation.
MouseEndotoxin/LPSC57BL/6Jn = Cumulative data from 3 independent experiments with 2 anima…Intravenous (external jugular vein)20 micrograms/kg per prostaglandinFirst dose given concurrently with intratracheal lipopolysaccharide instillation
Model: Acute lung injury induced by intratracheal instillation of Escherichia coli O55:B5 lipopolysaccharide (1 mg/kg body weight in 20 to 30 microlitres per Methods; the in vivo figure legend states 0.7 mg/kg intratracheally)
PGA2, PGE2 and PGI2 significantly reduced the lipopolysaccharide-induced rise in lavage cell counts and protein, PGD2 gave partial protection, whereas PGJ2 and PGF2alpha had no significant effect. Optical imaging confirmed reduced lung barrier dysfunction with PGA2, PGE2, PGI2 and PGD2.
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