THERAPY DOSSIER · th-78a6cc68395f

Prostaglandins PGE2, PGI2, PGA2, PGD2, PGF2alpha and PGJ2

Drug · Prostaglandin E2 receptor agonist (AGONIST)

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Evidence & regulatory context

Mechanism: Prostaglandin E2 receptor agonist (AGONIST)
Target: Prostaglandin E2 receptor (CHEMBL2363068)
Injury models: Endotoxin/LPS
Reported indication: Not recorded
First approval: 1977
Development stage: Not recorded
ChEMBL record: CHEMBL548 ↗
ChEMBL max phase: 4 / 4 (development scale, not regulatory approval)
Synonyms: Prostaglandin E2; Dinoprostone; Prostin E2; Cervidil; Prepidil
Note: Not recorded

Clinical trials 4

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT01720394 ↗PHASE4unknown

Induction of Labor Using a Double Balloon Catheter Compared to Dinoprostone Vaginal-insert - RCT

Cervical Ripening · Induction of Labor

Enrolment: 253 · Results not recorded

NCT01127581 ↗PHASE3completed

Phase III study of MVI 200 vs Dinoprostone Vaginal Insert (DVI) for reducing time to vaginal delivery in pregnant women at term

Reducing Time to Vaginal Delivery · Cervical Ripening · Induction of Labor

Enrolment: 1358 · Results not recorded

NCT02416583 ↗NAcompleted

Concurrent Oxytocin With Membrane Sweeping Versus Dinoprostone Pessary in Labor Induction of Nulliparas at Term

Failed Induction of Labor

Enrolment: 140 · Results not recorded

NCT02393144 ↗NAunknown

Analysis of Contemporary Labor Patterns Measured Via Transperineal Ultrasonography (Dinoprostone cervical ripening arm)

Pregnancy · Obstetric Labor

Enrolment: 1000 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 28663336 ↗2017Mixed findings

Effects of prostaglandin lipid mediators on agonist-induced lung endothelial permeability and inflammation.

MouseEndotoxin/LPSC57BL/6Jn = Cumulative data from 3 independent experiments with 2 anima…Intravenous (external jugular vein)20 micrograms/kg per prostaglandinFirst dose given concurrently with intratracheal lipopolysaccharide instillation

Model: Acute lung injury induced by intratracheal instillation of Escherichia coli O55:B5 lipopolysaccharide (1 mg/kg body weight in 20 to 30 microlitres per Methods; the in vivo figure legend states 0.7 mg/kg intratracheally)

PGA2, PGE2 and PGI2 significantly reduced the lipopolysaccharide-induced rise in lavage cell counts and protein, PGD2 gave partial protection, whereas PGJ2 and PGF2alpha had no significant effect. Optical imaging confirmed reduced lung barrier dysfunction with PGA2, PGE2, PGI2 and PGD2.

Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

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