RhoA Inhibitor Treatment At Acute Phase of Spinal Cord Injury May Induce Neurite Outgrowth and Synaptogenesis.
RatSpinal cord injuryCompressionn = Intraspinal delivery cohort n = 10 (saline n = 5, RhoA inhi…RhoA inhibitor intraspinal (bilateral, 1 mm from midline, 1.8 to 2 mm deep); FK506 intraperitonealRhoA inhibitor 0.1 micrograms/microlitre: two 2 microlitre…Single intraspinal RhoA inhibitor delivery 7 days after spinal cord injury
Model: Balloon compression spinal cord injury centred at the Th8 to Th9 level, with controls receiving no balloon inflation. Partial laminectomy at Th6 to Th12 performed 7 days after injury for intraspinal drug delivery.
Combined RhoA inhibitor and FK506 significantly increased synaptophysin-positive synaptic vesicle density at the lesion and produced an early rise in BBB score to 5.0, but the locomotor benefit did not persist and GAP-43 quantification did not differ from untreated injury.
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