Methylprednisolone Pulses and Tacrolimus in Severe Lung Injury Secondary to COVID-19
COVID-19 · Lung Injury
Enrolment: 84 · Results not recorded
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Drug · FK506-binding protein 1A (FKBP1A) inhibitor; calcineurin/immunophilin immunosuppressive pathway
6 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
COVID-19 · Lung Injury
Enrolment: 84 · Results not recorded
Ischemia Reperfusion Injury · Graft Dysfunction
Enrolment: 25 · Results not recorded
Hemorrhagic Cystitis
Enrolment: 13 · Results not recorded
Ischemic Reperfusion Injury · Organ Transplant Failure or Rejection
Enrolment: 414 · Results not recorded
Amputation, Traumatic · Wounds and Injuries · Hand Injuries
Enrolment: 30 · Results not recorded
Peripheral Nerve Injury
Enrolment: 0 · Results not recorded
Liver Transplantation
Enrolment: 92 · Results not recorded
Kidney Transplantation
Enrolment: 45 · Results not recorded
Liver Transplantation
Enrolment: 339 · Results not recorded
Lupus Nephritis · SLE
Enrolment: 20 · Results not recorded
Hepatitis C
Enrolment: 39 · Results not recorded
Pityriasis Alba
Enrolment: 39 · Results not recorded
Vitiligo
Enrolment: 120 · Results not recorded
Dermatitis, Atopic
Enrolment: 487 · Results not recorded
Atopic · Dermatitis
Enrolment: 200 · Results not recorded
Atopic Dermatitis
Enrolment: 148 · Results not recorded
Type 1 Diabetes Mellitus
Enrolment: 48 · Results not recorded
Acute Leukemia · Myelodysplastic Syndromes
Enrolment: 304 · Results not recorded
Liver Transplantation
Enrolment: 195 · Results not recorded
Atopic Dermatitis
Enrolment: 1110 · Results not recorded
7 studies reported at therapy level; 7 evidence entries itemised.
Model: Acute spinal cord contusion injury in adult rats, plus hypoxia-treated primary spinal cord microglia cultures
FK-506 reversed the rise in TNF-alpha, IL-1beta and IL-6 and the increased NF-kB activation seen 3 days after contusion, without altering microglial number.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.5. Machine-extracted fields require source verification.
Model: Peripheral nerve injury model of neuropathic pain with tactile allodynia
Intrathecal FK-506 or 11R-VIVIT given early after nerve injury attenuated the development of tactile allodynia and reduced NFATc4 and CCR2 mRNA in the dorsal root ganglia.
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.
Model: Lateral fluid percussion traumatic brain injury
The calcineurin inhibitor FK506 blocked TBI-induced cofilin changes in some brain regions, implicating calcineurin in dendritic spine remodelling.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: lateral fluid percussion TBI (moderate)
A single post-injury dose of FK506 prevented the TBI-induced loss of dendritic spines in rat forebrain.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Two full-thickness excisional skin wounds on the back
Tacrolimus-treated wounds showed healing patterns similar to vehicle, with slightly decreased IL-1 alpha and TGF-beta mRNA, whereas clobetasol propionate delayed re-epithelialisation and leucocyte infiltration.
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
Model: Laryngotracheal mucosal scrape injury with a nylon brush through a tracheostoma, producing acquired stenosis
Low-dose tacrolimus at 0.2 mg/kg significantly reduced airway stenosis at tracheal and cricoid levels versus untreated animals, with downregulation of nuclear factor of activated T cells and interleukin 2 in submucosal fibroblasts, neovascular cells and glandular cells. The higher 1.0 mg/kg dose ha…
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Model: Balloon compression spinal cord injury centred at the Th8 to Th9 level, with controls receiving no balloon inflation. Partial laminectomy at Th6 to Th12 performed 7 days after injury for intraspinal drug delivery.
Combined RhoA inhibitor and FK506 significantly increased synaptophysin-positive synaptic vesicle density at the lesion and produced an early rise in BBB score to 5.0, but the locomotor benefit did not persist and GAP-43 quantification did not differ from untreated injury.
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