Elental amino acid component has protective effects on primary cultured hepatocytes and a rat model of acute liver injury.
RatChemical/toxinSprague-Dawley and WistarMaleOral (dietary), with the Elental amino acid component given as pretreatment3% of each of the four amino acids in the dietPretreatment before D-galactosamine and lipopolysaccharide injection
Model: Acute liver injury induced by injection of D-galactosamine and lipopolysaccharide
The full Elental amino acid component inhibited iNOS induction in cultured hepatocytes but did not protect the liver in vivo, whereas the four amino acid combination of lysine, tryptophan, histidine and arginine increased survival by 50% and reduced hepatic inflammatory mediator expression and NF-k…
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