THERAPY DOSSIER · th-3cecdd43e0a4

Elental amino acid component (17 amino acids) and a four amino acid subset of lysine, tryptophan, histidine and arginine

Nutraceutical

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 1

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT01467765 ↗NAcompleted

Comparative study of elemental diet (Elental) and regular liquid diet on gastric emptying in patients with percutaneous endoscopic gastrostomy

Postprocedural Delayed Gastric Emptying

Enrolment: 20 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 28633873 ↗2017Mixed findings

Elental amino acid component has protective effects on primary cultured hepatocytes and a rat model of acute liver injury.

RatChemical/toxinSprague-Dawley and WistarMaleOral (dietary), with the Elental amino acid component given as pretreatment3% of each of the four amino acids in the dietPretreatment before D-galactosamine and lipopolysaccharide injection

Model: Acute liver injury induced by injection of D-galactosamine and lipopolysaccharide

The full Elental amino acid component inhibited iNOS induction in cultured hepatocytes but did not protect the liver in vivo, whereas the four amino acid combination of lysine, tryptophan, histidine and arginine increased survival by 50% and reduced hepatic inflammatory mediator expression and NF-k…

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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